Related Experiment Video
Updated: Apr 22, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
Published on: February 3, 2013
Adjusted p-values for SGoF multiple test procedure
Irene Castro-Conde1, Jacobo de Uña-Álvarez
1SiDOR Research Group, University of Vigo, Facultade de CC Económicas e Empresariais, Campus Lagoas-Marcosende, 36310 Vigo, Spain.
This study introduces adjusted p-values for the Sequential Goodness-of-Fit (SGoF) multiple test procedure, enhancing statistical power. These adjusted p-values offer a simplified computation and improved hypothesis rejection for various applications.
Area of Science:
- Statistics
- Statistical Methods
Background:
- Multiple comparison procedures are crucial for evaluating test statistics while accounting for multiplicity.
- The Sequential Goodness-of-Fit (SGoF) method is of significant interest for increasing statistical power in multiple testing scenarios.
Purpose of the Study:
- To introduce adjusted p-values for the SGoF multiple test procedure by allowing the test level to vary.
- To investigate the properties of these adjusted p-values and introduce a majorant version for enhanced hypothesis rejection.
Main Methods:
- The study defines adjusted p-values as the minimum level at which the SGoF procedure rejects a null hypothesis.
- It investigates properties such as being a subset of original p-values and introduces a majorant version and adjusted p-values for a conservative SGoF version.
- The handling of ties in p-values is also discussed.
Main Results:
- Adjusted p-values are shown to be a subset of original p-values, simplifying computation.
- The majorant version of the SGoF procedure demonstrates increased rejection of null hypotheses as the level increases.
- The study includes adjusted p-values for the conservative SGoF procedure and discusses tie handling.
Conclusions:
- The developed adjusted p-values extend the SGoF method, offering practical advantages for statistical power and hypothesis testing.
- The majorant and conservative versions, along with simplified computation, provide valuable tools for analyzing real-world data across various test sizes.
More Related Videos
Related Concept Videos
Bonferroni Test
The means of different samples are first paired in all possible combinations.
The null hypothesis of the...
Significance Testing: Overview
Test for Homogeneity
Decision Making: P-value Method
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can...
Identifying Statistically Significant Differences: The F-Test
P-value
P-value stands for the probability value. P-value is the probability that, if the null hypothesis is true, the results from another randomly selected sample will be as extreme or more extreme as the results obtained from the given sample.
A large P-value calculated from the data indicates to not reject the null hypothesis. But a higher P-value does not mean that the null hypothesis is true. The smaller the P-value, the more...

