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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
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Obesity and atopy.

L-P Boulet1

  • 1Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, QC, Canada.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|October 18, 2014
PubMed
Summary
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Obesity

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Area of Science:

  • Immunology
  • Public Health
  • Epidemiology

Background:

  • Global obesity prevalence is rising, impacting various health conditions like asthma.
  • The link between obesity and atopy (allergic sensitization) is unclear in adults and children.
  • Physiopathologic theories exist, but evidence for obesity influencing atopy development is inconsistent.

Purpose of the Study:

  • To investigate the uncertain relationship between obesity and atopy.
  • To explore how obesity might affect immune sensitization and allergic diseases.
  • To examine potential mediating roles of atopy in the obesity-asthma link.

Main Methods:

  • Review of existing literature and observational studies.
  • Analysis of data considering population characteristics, environment, and socioeconomic status.
  • Exploration of potential confounding factors and methodological variations.

Main Results:

  • Atopy does not generally mediate the obesity-asthma relationship, but exceptions exist in children and women.
  • The association between obesity and atopy varies across different atopic conditions, with some links to atopic dermatitis but not rhinoconjunctivitis.
  • Obesity's influence on atopy may be sex-hormone mediated, particularly in postpubertal females.

Conclusions:

  • The relationship between obesity and atopy is complex and influenced by various factors.
  • Further research is needed to clarify weight gain's impact on atopy and related diseases.
  • Understanding these links is crucial for public health strategies addressing obesity and allergic conditions.