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Cell death controlling complexes and their potential therapeutic role

Alexey V Zamaraev1, Gelina S Kopeina1, Boris Zhivotovsky2,3

  • 1Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia.

Cellular and Molecular Life Sciences : CMLS
|October 18, 2014
PubMed

Insights

Programmed cell death regulation involves multiprotein complexes. Targeting these platforms offers new therapeutic strategies for diseases like cancer and autoimmune disorders.

Area of Science:

  • Cellular biology
  • Molecular mechanisms of cell death

Background:

  • Programmed cell death is crucial for multicellular organism homeostasis and development.
  • Aberrant cell death contributes to diseases such as cancer and autoimmune disorders.
  • Cell death initiation involves multiprotein complexes that dictate cellular fate.

Purpose of the Study:

  • To detail key cell-death complexes controlling apoptosis and necroptosis.
  • To discuss the regulation of these molecular platforms.
  • To explore the potential for pharmacological targeting of these complexes.

Main Methods:

  • Review and detailed discussion of known cell-death complexes.
  • Analysis of molecular interactions within these platforms.
  • Exploration of regulatory mechanisms governing cell death pathways.

Main Results:

  • Identified and described key complexes: DISC, complex II, TNFRI complex I/II, necrosome, RIPoptosome, apoptosome, and PIDDosome.
  • Highlighted the influence of complex composition and structure on cell death induction.
  • Underscored the role of these platforms in apoptosis and necroptosis pathways.

Conclusions:

  • Cell-death complexes are critical regulators of apoptosis and necroptosis.
  • Understanding these platforms is key to understanding cell death.
  • Pharmacological targeting of these high molecular weight platforms presents novel therapeutic avenues.

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