[Effect of glucagon on the development of delayed hypersensitivity to alloantigens in mice]

A study was made of the effect of different doses of glucagon (0.02, 0.1, 0.5, 2.5 micrograms) on the expression of delayed type hypersensitivity (DTH) in CBA mice. DTH was induced by local administration of allogenic cells, namely mouse splenocytes F1 (CBA X C57BL/6). The suppressive effect of 0.5 and 2.5 micrograms of glucagon and 0.1 micrograms of this hormone when combined with antigen (in the same syringe) on DTH development was revealed. Glucagon action was manifested in the inductive and effector phases of the DTH reaction. Special tests have shown that the glucagon immunosuppressive effect was unassociated with hyperglycemia and mediated by the activation of antigen specific DTH T-suppressors.