Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.6K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.0K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

199
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
199
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

271
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
271
Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

213
Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
213

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Unfinished Story: Analyzing Publication Rates in Diabetic Retinopathy and Diabetic Macular Edema Trials Before the COVID-19 Era (1972-2018).

Rhode Island medical journal (2013)·2025
Same author

Comparative Study of Adalimumab, Infliximab and Certolizumab Pegol in the Treatment of Cystoid Macular Edema Due to Behçet's Disease.

Journal of clinical medicine·2024
Same author

Comparing Prednisone and Methotrexate to Off-label Biologic Infliximab for Management of Ocular Uveitis: A Cost-minimization Analysis.

Journal of health economics and outcomes research·2023
Same author

Bilateral Occlusive Retinal Vasculitis in a Patient with Dermatomyositis.

Middle East African journal of ophthalmology·2023
Same author

Correction to: Validation of UVEDAI: An Index for Evaluating the Level of Inflammatory Activity in Uveitis.

Ophthalmology and therapy·2023
Same author

Validation of UVEDAI: An Index for Evaluating the Level of Inflammatory Activity in Uveitis.

Ophthalmology and therapy·2023

Related Experiment Video

Updated: Apr 22, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

5.3K

Drug-induced uveitis.

Miguel Cordero-Coma1, Raquel Salazar-Méndez, Irene Garzo-García

  • 1Department of Ophthalmology, University Hospital of León , León , Spain +34 987237400 ; +34 987233322 ; miguelcorderocoma@gmail.com.

Expert Opinion on Drug Safety
|October 18, 2014
PubMed
Summary
This summary is machine-generated.

Drug-induced uveitis, an adverse reaction to medication, can cause intraocular inflammation. Awareness of potential drug effects is crucial for accurate diagnosis and management of uveitis cases.

Keywords:
VEGFbisphosphonatescidofovirdiethylcarbamazinedrug-induced uveitisdrug-related side effectsmetipranololprostaglandinsquinolonesrifabutinsulfonamidesuveitisvaccines

More Related Videos

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

4.3K
Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
06:57

Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis

Published on: March 8, 2018

8.4K

Related Experiment Videos

Last Updated: Apr 22, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

5.3K
Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

4.3K
Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
06:57

Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis

Published on: March 8, 2018

8.4K

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Toxicology

Background:

  • Drug-induced uveitis is an underdiagnosed adverse reaction to medications.
  • Numerous drugs are increasingly linked to intraocular inflammation.
  • Identifying causative agents aids in diagnosing new uveitis cases.

Purpose of the Study:

  • Provide a practical guide on drugs associated with uveitis.
  • Examine potential mechanisms of drug-induced uveitis.
  • Offer clinical guidance for managing patients with uveitis.

Main Methods:

  • Comprehensive literature review of drug-induced uveitis.
  • Application of Naranjo et al. causality classification (1981).
  • Analysis of proposed mechanisms of action for ocular inflammation.

Main Results:

  • Various systemic, topical, and intraocular drugs can induce uveitis.
  • Mechanisms of drug-induced ocular inflammation are often unclear.
  • Clinicians need to consider drug effects in uveitis diagnosis.

Conclusions:

  • Drug-induced uveitis requires clinical awareness for proper diagnosis.
  • Understanding drug associations can optimize patient management.
  • Further research into mechanisms may improve treatment strategies.