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Coxsackievirus B infection is highly related with missed abortion in Korea
Jung Hye Hwang1, Jeong Wook Kim1, Ji Young Hwang2
1Department of Obstetrics and Gynecology, College of Medicine, Hanyang University, Seoul, Korea.
Purpose:
This study investigated the possible relationship between viral infection and first trimester pregnancy loss.
Materials And Methods:
A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tem delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confirmed by genome sequencing. Herpesviruses were detected by PCR.
Results:
Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases.
Conclusion:
The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.
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