Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

10.5K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
10.5K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

63.9K
Overview
63.9K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.7K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.7K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

14.1K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.1K
Humoral Immune Responses01:36

Humoral Immune Responses

65.3K
Overview
65.3K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

6.7K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas.

The Journal of experimental medicine·2026
Same author

Intestinal intraepithelial lymphocyte migration and tissue homeostasis are dictated by Gα13.

bioRxiv : the preprint server for biology·2026
Same author

ABCC1 protects skin dendritic cells from FITC-induced toxicity by efflux and extracellular glutathione buffering.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes.

The Journal of experimental medicine·2026
Same author

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation.

The Journal of experimental medicine·2026
Same author

Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses.

Cell·2025

Related Experiment Video

Updated: Apr 22, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

33.7K

25-Hydroxycholesterols in innate and adaptive immunity.

Jason G Cyster1, Eric V Dang2, Andrea Reboldi2

  • 11] Department of Microbiology and Immunology, University of California San Francisco, California 94143-0414, USA. [2] Howard Hughes Medical Institute, University of California San Francisco, California 94143-0414, USA.

Nature Reviews. Immunology
|October 18, 2014
PubMed
Summary

Hydroxylated cholesterol forms regulate immune function by influencing the cholesterol pathway and cell membranes. These oxysterols are crucial for antiviral, anti-inflammatory, and adaptive immune responses.

More Related Videos

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

2.2K
LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

13.2K

Related Experiment Videos

Last Updated: Apr 22, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

33.7K
Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

2.2K
LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

13.2K

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • Cholesterol and its biosynthetic pathway are vital for mammalian cells.
  • Hydroxylated cholesterol derivatives, or oxysterols, are increasingly recognized as key immune regulators.
  • These compounds impact cell membrane properties and biosynthetic pathways, influencing immune responses.

Purpose of the Study:

  • To review the roles of 25-hydroxycholesterol and 7α,25-dihydroxycholesterol in immunity.
  • To summarize current knowledge on oxysterol-mediated immune regulation.

Main Methods:

  • Literature review of studies on oxysterols and immune function.
  • Analysis of the mechanisms by which oxysterols affect immune cells and pathways.

Main Results:

  • Oxysterols modulate the cholesterol biosynthetic pathway and cell membrane properties.
  • They exhibit antiviral and anti-inflammatory effects.
  • 7α,25-dihydroxycholesterol acts as an immune cell guidance cue via the EBI2 receptor, essential for adaptive immunity.

Conclusions:

  • 25-hydroxycholesterol and 7α,25-dihydroxycholesterol have broad impacts on both innate and adaptive immunity.
  • Understanding these oxysterols is critical for иммунологических research and potential therapeutic strategies.