Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microbial Bioremediation of Uranium

Microbial Bioremediation of Uranium

Microorganisms play a critical role in the transformation and immobilization of uranium in contaminated environments through four main pathways: bioreduction, biosorption, bioaccumulation, and biomineralization. These mechanisms reduce uranium’s toxicity and prevent its migration through groundwater systems, offering sustainable approaches for in situ bioremediation.Bioreduction of UraniumBioreduction is driven by anaerobic bacteria such as certain strains of Geobacter and Shewanella,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Peering Through the Polymer: Tracking Small Molecules to Improve Polymer Development.

Macromolecules·2026

Same author

Impact of the spatial distribution of positive charges on the catalytic activity of NiSOD bioinspired complexes.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry·2026

Same author

Surface Modification of Polyesters Using Biosourced Soil-Release Polymers.

JACS Au·2025

Same author

Biomimetic Pseudopeptides to Decipher the Interplay between Cu and Methionine-Rich Domains in Proteins.

Chemistry (Weinheim an der Bergstrasse, Germany)·2024

Same author

Hydrophilic interaction liquid chromatography: An efficient tool for assessing thorium interaction with phosphorylated biomimetic peptides.

Journal of chromatography. A·2024

Same author

Field-domain rapid-scan EPR at 240GHz for studies of protein functional dynamics at room temperature.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2024

Search research articles

Related Experiment Video

Updated: Apr 22, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Engineering short peptide sequences for uranyl binding.

Colette Lebrun¹, Matthieu Starck, Vicky Gathu

¹Univ. Grenoble Alpes, INAC, SCIB, 38000 Grenoble (France); CEA, INAC, SCIB, 38054 Grenoble (France).

Chemistry (Weinheim an Der Bergstrasse, Germany)

|October 18, 2014

Summary

This summary is machine-generated.

Cyclic peptides with specific structures can effectively bind uranyl, a key factor in uranium toxicity. Glutamate-rich cyclodecapeptides show the highest affinity, offering a promising design for uranyl-chelating agents.

Keywords:

bioinorganic chemistry carboxylate ligands fluorescence peptides uranium

More Related Videos

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy

Published on: March 6, 2017

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression

Published on: February 3, 2023

Related Experiment Videos

Last Updated: Apr 22, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy

Published on: March 6, 2017

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression

Published on: February 3, 2023

Area of Science:

Biochemistry
Toxicology
Supramolecular Chemistry

Background:

Uranyl-protein interactions are crucial for understanding uranium toxicity in vivo.
Structured cyclic peptides offer pre-oriented amino acid side chains for coordinating uranyl.

Purpose of the Study:

To investigate uranyl binding by decapeptides.
To identify key parameters for stable uranyl-peptide complex formation.
To evaluate the role of peptide structure in uranyl affinity.

Main Methods:

Complementary analytical methods.
Spectroscopic methods (e.g., molar ellipticity at 195 nm).
Affinity determination for uranyl-cyclodecapeptide complexes.

Main Results:

Molar ellipticity at 195 nm correlates directly with uranyl complex stability.
Beta-sheet structures are optimal for high peptide-based uranyl complex stability.
Cyclodecapeptides with four glutamate residues exhibit the highest uranyl affinities (log KC = 8.0–8.4).

Conclusions:

Peptide secondary structure significantly influences uranyl binding affinity.
Glutamate-rich cyclodecapeptides are effective uranyl chelators.
These findings provide a basis for designing high-affinity uranyl-chelating peptides for toxicological applications.