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Updated: Apr 21, 2026
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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
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Comorbidities in infants with obstructive sleep apnea.
William F Qubty1, Anna Mrelashvili1, Suresh Kotagal2
1Division of Child Neurology, Mayo Clinic, Rochester, MN.
Summary
Infants with obstructive sleep apnea (OSA) often have unique comorbidities like reflux and genetic syndromes, differing from older children. Early recognition and a multidisciplinary approach are key for effective infant OSA management.
Area of Science:
- Pediatric Sleep Medicine
- Respiratory Medicine
- Genetics
Background:
- Obstructive sleep apnea (OSA) in infants is not well-characterized.
- Identifying comorbidities can aid in earlier diagnosis and improved management of infant OSA.
Purpose of the Study:
- To describe common comorbidities in infants diagnosed with obstructive sleep apnea (OSA).
- To provide insights for earlier recognition and better management strategies for infant OSA.
Main Methods:
- Retrospective, single-center study of 139 infants (0-17 months) with OSA diagnosed via polysomnography (PSG).
- Exclusion criteria included >50% central apnea events.
- OSA severity classified using the apnea-hypopnea index (AHI).
Main Results:
- Gastroesophageal reflux (68%), periodic limb movements (42%), and craniofacial abnormalities (37%) were common comorbidities.
- OSA severity correlated with prematurity, genetic syndromes, and neuromuscular abnormalities.
- 86% of infants required multispecialty evaluations.
Conclusions:
- Infant OSA comorbidities differ from those in older children.
- Effective management necessitates a multidisciplinary approach involving genetics, gastroenterology, pulmonology, otolaryngology, neurology, and pediatrics.
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