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Obstructive sleep apnea is associated with impaired exercise capacity: a cross-sectional study
Jeremy R Beitler1, Karim M Awad2, Jessie P Bakker3
1Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Summary
Obstructive sleep apnea (OSA) is linked to reduced exercise capacity. Cardiopulmonary exercise testing (CPET) may help assess cardiovascular risk in OSA patients.
Area of Science:
- Cardiology
- Sleep Medicine
- Exercise Physiology
Background:
- Obstructive sleep apnea (OSA) increases cardiovascular event risk.
- Cardiopulmonary exercise testing (CPET) is used for heart disease prognosis.
- The impact of OSA on exercise capacity requires further clarification.
Purpose of the Study:
- To test the hypothesis that OSA impairs exercise capacity.
- To investigate the relationship between OSA severity and exercise performance.
Main Methods:
- Fifteen moderate-to-severe OSA patients and 19 controls underwent polysomnography.
- Resting metabolic rate was measured by indirect calorimetry.
- Symptom-limited CPET was performed to assess peak oxygen uptake (V˙O2).
Main Results:
- OSA patients had significantly lower percent predicted peak V˙O2 than controls (70.1% vs 83.8%, p=0.02).
- Increased apnea-hypopnea index (AHI) correlated with decreased V˙O2 (p=0.02).
- AHI explained 16.1% of the variability in V˙O2 (p=0.02).
Conclusions:
- OSA is associated with impaired exercise capacity.
- CPET may be valuable for cardiovascular risk stratification in OSA.
- Further research is warranted to confirm CPET's prognostic utility in OSA.
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