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Related Concept Videos

Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Apr 21, 2026

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
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Published on: November 17, 2014

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Corneal transplantation and glaucoma.

Ramez I Haddadin1, James Chodosh

  • 1Massachusetts Eye & Ear Infirmary, Ophthalmology, Cornea & Refractive Surgery Service, Harvard Medical School , Boston, Massachusetts , USA.

Seminars in Ophthalmology
|October 18, 2014
PubMed
Summary
This summary is machine-generated.

Glaucoma is a major cause of vision loss and graft failure after corneal transplants. Newer keratoplasty techniques may offer reduced glaucoma risks compared to traditional methods.

Keywords:
DALKDMEKDSEKkeratoplastykeratoprosthesisocular hypertension

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Area of Science:

  • Ophthalmology
  • Corneal Transplantation
  • Glaucoma Management

Background:

  • Glaucoma is a leading cause of irreversible vision loss and graft failure following keratoplasty.
  • The increasing use of novel keratoplasty techniques necessitates a review of their associated glaucoma risks.

Purpose of the Study:

  • To review the incidence, risks, evaluation, and management of glaucoma in the context of various keratoplasty procedures.
  • To compare glaucoma complications across different corneal transplant types.

Main Methods:

  • A comprehensive literature search was conducted on glaucoma in eyes undergoing corneal transplantation.
  • The review synthesizes findings on risk factors and management strategies.

Main Results:

  • Preexisting glaucoma and aphakia are significant risk factors for post-keratoplasty glaucoma.
  • Deep anterior lamellar keratoplasty (DALK) may be associated with lower rates of post-keratoplasty glaucoma.
  • Descemet stripping endothelial keratoplasty (DSEK) generally presents less severe glaucoma and more manageable intraocular pressure compared to penetrating keratoplasty (PK).
  • Endothelial keratoplasty (EK) introduces specific perioperative challenges, particularly concerning anterior chamber air bubbles.

Conclusions:

  • The choice of keratoplasty technique impacts the risk and management of post-keratoplasty glaucoma.
  • Clinicians must weigh glaucoma considerations when selecting the most appropriate corneal transplant method.
  • DALK and DSEK may offer advantages in reducing glaucoma complications compared to PK.