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Recent developments in therapeutic protein expression technologies in plants.

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Plants are emerging as efficient bioreactors for producing therapeutic proteins. This review covers advances in plant-made pharmaceuticals, including vaccines and antibodies, for treating diseases.

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Plant Sciences

Background:

  • Infectious diseases and cancers are leading global causes of mortality.
  • Recombinant DNA technology enables the production of therapeutic proteins.
  • Plants are being explored as novel expression systems for biopharmaceuticals.

Purpose of the Study:

  • To review recent progress in expressing therapeutic proteins in plants.
  • To discuss factors influencing heterologous protein expression in plants.
  • To highlight advancements in plant-based vaccine and antibody production.

Main Methods:

  • Review of scientific literature on plant-based protein expression.
  • Analysis of stable and transient expression systems in plants.
  • Examination of vector systems and technological developments.

Main Results:

  • Plants offer a viable system for producing recombinant therapeutic proteins.
  • Factors affecting expression levels and product quality have been identified.
  • Progress has been made in developing plant-made vaccines, antibodies, and biopharmaceuticals.

Conclusions:

  • Plant-based biopharmaceutical production is a promising field.
  • Further development is needed for industrial-scale production.
  • Plant-made biologics hold potential for treating infectious diseases and cancers.