Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

1.9K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.9K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

1.4K
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.4K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

152
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
152
Conduct Disorder01:28

Conduct Disorder

977
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
977
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

1.6K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.6K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

2.5K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Depressive symptoms and their associations with positive psychosocial factors among medical students.

Medicine·2026
Same author

Extended editorial: preventing fraud and cybercrime in an ageing society.

Security journal·2025
Same author

Risperidone Augmentation in Antidepressant-Resistant Somatic Symptom Disorder.

Psychiatry and clinical psychopharmacology·2025
Same author

The Impact of Sexual Violence Victimization on Acculturative Stress and Hazardous Drinking Among North Korean Refugee Women in South Korea.

Violence against women·2024
Same author

Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia.

Asian journal of psychiatry·2024
Same author

Navigating AI transitions: how coaching leadership buffers against job stress and protects employee physical health.

Frontiers in public health·2024

Related Experiment Video

Updated: Apr 21, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.6K

Dopaminergic Polymorphisms, Academic Achievement, and Violent Delinquency.

Ilhong Yun1, Julak Lee2, Seung-Gon Kim1

  • 1Chosun University, Gwangju, South Korea.

International Journal of Offender Therapy and Comparative Criminology
|October 19, 2014
PubMed
Summary

Self-control significantly impacts adolescent academic performance, outweighing genetic influences from dopaminergic genes (dopamine transporter [DAT1], dopamine D2 receptor [DRD2], and dopamine D4 receptor [DRD4]). Academic success also mediates the link between these genes and violent delinquency.

Keywords:
academic performancedelinquencydopaminegenetics

More Related Videos

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

25.3K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.1K

Related Experiment Videos

Last Updated: Apr 21, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.6K
Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

25.3K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.1K

Area of Science:

  • Educational Psychology
  • Molecular Genetics
  • Behavioral Genetics

Background:

  • Self-control is a key factor in students' academic achievement.
  • Genetic variations in dopaminergic genes (DAT1, DRD2, DRD4) are associated with adolescent GPAs.
  • The interplay between genetics, environment, and academic outcomes requires further investigation.

Purpose of the Study:

  • To compare the influence of self-control versus dopaminergic gene polymorphisms on adolescent GPAs.
  • To examine gene-environment interactions affecting academic performance.
  • To investigate the mediating role of GPAs in the relationship between dopaminergic genes and violent delinquency.

Main Methods:

  • Reanalysis of the Add Health genetic subsample.
  • Statistical assessment of self-control and dopaminergic gene effects on GPAs.
  • Examination of gene-environment interactions and mediation analyses.

Main Results:

  • Self-control demonstrated a stronger effect on GPAs than dopaminergic genes.
  • Gene-environment interactions supported the "social push hypothesis."
  • Academic performance fully mediated the association between dopaminergic genes and violent delinquency.

Conclusions:

  • Self-control is a more potent predictor of academic success than the studied dopaminergic genes.
  • Environmental factors interact with genetics to influence academic outcomes.
  • Targeting academic performance may be crucial for mitigating gene-related risks for delinquency.