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SFTS virus infection in nonhuman primates

Cong Jin1, Hong Jiang2, Mifang Liang1

  • 1Key Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC.

The Journal of Infectious Diseases
|October 19, 2014
PubMed

Insights

Severe fever with thrombocytopenia syndrome virus (SFTSV) causes mild illness in rhesus macaques, unlike its severe effects in humans. This study details the nonhuman primate response to SFTSV infection.

Area of Science:

  • Virology
  • Infectious Diseases
  • Primate Models

Background:

  • Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by the SFTS virus (SFTSV).
  • While mice are susceptible to SFTSV, its effects in nonhuman primates remained uninvestigated.

Purpose of the Study:

  • To investigate the susceptibility and pathological effects of SFTSV infection in rhesus macaques.
  • To characterize the clinical, immunological, and pathological responses to SFTSV in a nonhuman primate model.

Main Methods:

  • Rhesus macaques were infected with SFTSV.
  • Clinical signs, hematological and biochemical parameters, viral loads, antibody responses, cytokine profiles, and pathological lesions were monitored.

Main Results:

  • SFTSV infection in macaques resulted in mild symptoms including fever, thrombocytopenia, leukocytopenia, and elevated liver and myocardial enzymes.
  • Viremia and robust humoral immune responses (IgM, IgG, neutralizing antibodies) were detected in all infected animals.
  • Elevated levels of pro-inflammatory cytokines (IFN-γ, TNF-α, etc.) and minor liver/kidney lesions were observed.

Conclusions:

  • Rhesus macaques are susceptible to SFTSV but develop a milder form of the disease compared to severe human cases.
  • This model offers a valuable platform for studying SFTSV pathogenesis and evaluating potential therapeutics.
Keywords:
SFTS virusinfectious animal modelnonhuman primatepathogenesis

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