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Related Experiment Video

Updated: Apr 21, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

SFTS virus infection in nonhuman primates.

Cong Jin¹, Hong Jiang², Mifang Liang¹

¹Key Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC.

The Journal of Infectious Diseases

|October 19, 2014

Summary

Severe fever with thrombocytopenia syndrome virus (SFTSV) causes mild illness in rhesus macaques, unlike its severe effects in humans. This study details the nonhuman primate response to SFTSV infection.

Keywords:

SFTS virus infectious animal model nonhuman primate pathogenesis

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Area of Science:

Virology
Infectious Diseases
Primate Models

Background:

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by the SFTS virus (SFTSV).
While mice are susceptible to SFTSV, its effects in nonhuman primates remained uninvestigated.

Purpose of the Study:

To investigate the susceptibility and pathological effects of SFTSV infection in rhesus macaques.
To characterize the clinical, immunological, and pathological responses to SFTSV in a nonhuman primate model.

Main Methods:

Rhesus macaques were infected with SFTSV.
Clinical signs, hematological and biochemical parameters, viral loads, antibody responses, cytokine profiles, and pathological lesions were monitored.

Main Results:

SFTSV infection in macaques resulted in mild symptoms including fever, thrombocytopenia, leukocytopenia, and elevated liver and myocardial enzymes.
Viremia and robust humoral immune responses (IgM, IgG, neutralizing antibodies) were detected in all infected animals.
Elevated levels of pro-inflammatory cytokines (IFN-γ, TNF-α, etc.) and minor liver/kidney lesions were observed.

Conclusions:

Rhesus macaques are susceptible to SFTSV but develop a milder form of the disease compared to severe human cases.
This model offers a valuable platform for studying SFTSV pathogenesis and evaluating potential therapeutics.