Related Experiment Video
Updated: Apr 21, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Emerging molecular phenotypes of asthma.
Anuradha Ray1, Timothy B Oriss1, Sally E Wenzel2
1University of Pittsburgh Asthma Institute at UPMC, Pulmonary, Allergy and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Asthma is a complex disease with distinct subtypes. Research is evolving from clinical asthma phenotypes to molecular phenotypes, enabling targeted therapies and personalized medicine.
Area of Science:
- Pulmonology
- Genetics
- Immunology
Background:
- Asthma is recognized as a heterogeneous respiratory condition.
- Previous efforts to classify asthma subtypes have been constrained.
- Recent advancements integrate clinical, biological, and genetic data.
Purpose of the Study:
- To define distinct asthma phenotypes.
- To transition from clinical to molecular asthma phenotypes.
- To support the development of targeted therapies.
Main Methods:
- Utilized combined clinical and statistical approaches.
- Incorporated multi-omics data and molecular pathway analysis.
- Integrated genetic and environmental interaction data.
Main Results:
- Identified consistent clinical asthma phenotypes across studies.
- Demonstrated the shift towards molecular phenotypes.
- Confirmed the utility of molecular phenotypes in guiding therapy.
Conclusions:
- The classification of asthma is moving towards molecular phenotypes.
- Molecular phenotypes are crucial for developing targeted biological therapies.
- The singular term 'asthma' may be replaced by more specific disease classifications.
More Related Videos
09:58A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
Published on: April 13, 2010
08:44Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
Published on: May 30, 2020
Related Concept Videos
Asthma I: Introduction
Asthma III: Clinical Manifestations
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction
Asthma-III: Symptoms and Complications
Classification of Asthma