Related Experiment Video
Updated: Apr 21, 2026
09:20
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
6.1K
Current perspectives on systemic hypertension in heart failure with preserved ejection fraction
1Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N. St. Clair St., Suite 600, Chicago, IL, 60611, USA.
Current Cardiology Reports
|October 20, 2014
Summary
Hypertension significantly contributes to heart failure with preserved ejection fraction (HFpEF). Controlling blood pressure is crucial for managing HFpEF and preventing its development.
Area of Science:
- Cardiology
- Nephrology
- Internal Medicine
Background:
- Hypertension is a primary driver of heart failure with preserved ejection fraction (HFpEF).
- Recent research has deepened the understanding of the complex interplay between hypertension and HFpEF.
- The relationship extends beyond left ventricular hypertrophy and diastolic dysfunction.
Purpose of the Study:
- To review the epidemiology and pathophysiology of HFpEF in the context of hypertension.
- To discuss the prevention of HFpEF through hypertension control.
- To explore established and novel therapeutic strategies for hypertension in HFpEF patients.
Main Methods:
- Literature review focusing on hypertension and HFpEF.
- Analysis of epidemiological data.
- Examination of pathophysiological mechanisms.
- Evaluation of therapeutic interventions.
Main Results:
- Hypertension's role in HFpEF is multifaceted, involving interactions with comorbidities and the vasculature.
- Effective blood pressure control is essential for HFpEF management.
- Understanding the complex relationship aids in prevention and treatment strategies.
Conclusions:
- Hypertension is a critical factor in HFpEF development and progression.
- Comprehensive management strategies targeting hypertension are vital for HFpEF patients.
- Further research into novel therapeutics holds promise for improving outcomes.
Related Concept Videos
01:17Pathophysiology of Heart Failure
4.4K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.4K
01:29Heart Failure II: Pathophysiology
1.4K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.4K
01:30Heart Failure V: Medical Management
606
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
606
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
1.5K
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.5K
01:27Heart Failure I: Introduction
1.3K
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.3K
01:22Heart Failure Drugs: Diuretics
1.3K
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.3K