Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dapsone-induced erythroderma with Beau's lines.

A H Patki, J M Mehta

    Leprosy Review
    |December 1, 1989
    PubMed
    Summary

    Dapsone-induced erythroderma in leprosy patients can cause nail changes and requires prompt dermatological evaluation. Early recognition and management of this hypersensitivity reaction are crucial for patient recovery.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Biometrical evaluation of the performance of the revised OECD Test Guideline 402 for assessing acute dermal toxicity.

    Regulatory toxicology and pharmacology : RTP·2017
    Same author

    Incontinentia Pigmenti Stage - II.

    Indian journal of dermatology, venereology and leprology·2017
    Same author

    Profile of oral squamous cell cancer in a tertiary level medical college hospital: a 10 yr study.

    Indian journal of surgical oncology·2013
    Same author

    Epidemic dropsy: Epidemiological, clinical & therapeutic observations in 67 cases. 1969.

    The Indian journal of medical research·2013
    Same author

    Dual wavelength interferometric technique for simultaneous temperature and concentration measurements in liquids.

    Applied optics·2010
    Same author

    Errors associated with interferometric measurement of convective heat transfer coefficients.

    Applied optics·2010

    Area of Science:

    • Dermatology
    • Leprosy Research
    • Adverse Drug Reactions

    Background:

    • Leprosy management often involves multidrug therapy (MDT), including dapsone.
    • Dapsone hypersensitivity reactions can manifest with severe dermatological symptoms.
    • Borderline lepromatous (BL) leprosy presents a specific clinical context for evaluating drug toxicity.

    Observation:

    • A 35-year-old female with BL leprosy developed erythroderma after starting dapsone therapy.
    • The erythroderma was associated with Beau's lines, indicating nail matrix dysfunction.
    • The patient experienced rapid improvement upon dapsone withdrawal and corticosteroid treatment.

    Findings:

    • Dapsone-induced erythroderma is a significant adverse reaction in leprosy patients.
    • Nail matrix arrest, evidenced by Beau's lines, can occur during severe skin reactions.
    • Systemic corticosteroids and emollients are effective in managing dapsone-induced erythroderma.

    Implications:

    • Patients on MDT for leprosy require vigilant monitoring for skin rashes, especially within the first two months.
    • Urgent dermatological referral is recommended for leprosy patients presenting with skin rash during early treatment.
    • Recognizing and managing dapsone hypersensitivity promptly can prevent severe complications and ensure treatment continuity.

    Related Experiment Videos