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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Cardiac tamponade presenting as early manifestation in dengue fever
Abstract:
Dengue fever (DF) is an outbreak prone viral disease transmitted by aedes mosquitoes. It is often associated with evidence of plasma leakage due to increased vascular permeability manifested by pleural effusion, ascites, hypoproteinaemia and pericardial effusion. Cases of small pericardial effusion have been reported in association with dengue fever, largely with dengue haemorrhagic fever (DHF) during epidemic outbreaks. Dengue may rarely present with cardiac tamponade as early manifestation and urgent pericardiocentesis is life saving. A 34 year old male presented with low grade fever, headache, myalgia and breathlessness. Echocardiography revealed large pericardial effusion with right ventricular diagnostic collapse requiring urgent drainage. Subsequently patient improved. Dengue serology (both IgM and IgG) was reported as markedly elevated supporting a diagnosis of classic dengue fever.
Insights
Dengue fever can rarely cause cardiac tamponade, a life-threatening condition. Early diagnosis and drainage of pericardial effusion in dengue patients are crucial for survival.
Area of Science:
- Cardiology
- Infectious Diseases
- Virology
Background:
- Dengue fever (DF) is a mosquito-borne viral illness known for causing plasma leakage and effusions.
- Pericardial effusion is an uncommon but serious complication of dengue, particularly during outbreaks.
Observation:
- A 34-year-old male presented with symptoms including fever, headache, myalgia, and breathlessness.
- Echocardiography revealed a large pericardial effusion with right ventricular collapse, necessitating urgent drainage.
Findings:
- The patient's condition improved significantly after the pericardial effusion was drained.
- Elevated dengue-specific IgM and IgG antibodies confirmed the diagnosis of classic dengue fever.
Implications:
- This case highlights dengue fever's potential to present with cardiac tamponade as an early manifestation.
- Prompt recognition and intervention, such as pericardiocentesis, can be life-saving in managing dengue-associated cardiac complications.
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