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Updated: Apr 21, 2026

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Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
Published on: January 31, 2014
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Conducting polymer nanoparticles decorated with collagen mimetic peptides for collagen targeting
José Luis Santos1, Yang Li, Heidi R Culver
1Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA. herrera@jhu.edu.
Abstract:
We report on the formation of conducting polymer nanoparticles (CPNs), stabilized by a collagen mimetic peptide (CMP)-polymer amphiphile. CPNs ranging from ∼15 to 40 nm were readily accessible upon modifying the amphiphile concentration. Surface presentation of CMPs on CPN precluded intra-/inter-particle trimerization, while preserving their ability to target collagen without pre-activation.

