Integration of nanoassembly functions for an effective delivery cascade for cancer drugs
Qihang Sun1, Xuanrong Sun, Xinpeng Ma
1Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China, 310027; Department of Chemical Engineering, University of Wyoming, Laramie, WY, USA, 82071.
Abstract:
A "cluster-bomb"-like lipid-dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like "bomblets", enabling tumor penetration, cell internalization, and drug release.
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