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Primary leiomyosarcoma of the mandible
Saede Atarbashi Moghadam1, Abbas Khodayari2, Sepideh Mokhtari1
1Department of Oral and Maxillofacial Pathology, Dental School of Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Journal of Oral and Maxillofacial Pathology : JOMFP
|October 21, 2014
Summary
This case report details an extremely rare oral cavity leiomyosarcoma (LMS) in a 67-year-old woman. Diagnosis was confirmed via immunohistochemistry, highlighting the importance of considering rare soft tissue tumors.
Area of Science:
- Oncology
- Pathology
- Oral Medicine
Background:
- Leiomyosarcoma (LMS) is a rare malignant soft tissue neoplasm originating from smooth muscle.
- Oral cavity LMS is exceptionally uncommon, presenting diagnostic challenges.
Observation:
- A 67-year-old female presented with a 9-month history of a painful mandibular lesion.
- Histopathological examination revealed spindle-shaped cells with characteristic nuclear and cytoplasmic features.
Findings:
- Immunohistochemistry confirmed smooth muscle differentiation, with tumor cells positive for smooth muscle actin (SMA) and desmin.
- These findings are consistent with a diagnosis of leiomyosarcoma.
Implications:
- This case underscores the rarity of oral LMS and the importance of comprehensive histopathological and immunohistochemical evaluation.
- Accurate diagnosis is crucial for appropriate management and prognosis of soft tissue sarcomas in the oral cavity.
