Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

P53 and oncogenes expression in psoriasis.

G Tadini1, A Cerri, L Crosti

  • 11st Department of Dermatology, University of Milan, Italy.

Acta Dermato-Venereologica. Supplementum
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of the Soft-Drop Jet Mass in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2018
Same author

Measurement of jet fragmentation in Pb+Pb and

The European physical journal. C, Particles and fields·2018
Same author

Precision measurement and interpretation of inclusive

The European physical journal. C, Particles and fields·2018
Same author

Search for new phenomena using the invariant mass distribution of same-flavour opposite-sign dilepton pairs in events with missing transverse momentum in

The European physical journal. C, Particles and fields·2018
Same author

Search for Low-Mass Dijet Resonances Using Trigger-Level Jets with the ATLAS Detector in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2018
Same author

Search for the Decay of the Higgs Boson to Charm Quarks with the ATLAS Experiment.

Physical review letters·2018
Same journal

Atopic eczema - new insights in the definition, diagnostics and disease management. Proceedings of a LEO eczema workshop. November 2003. Copenhagen, Denmark.

Acta dermato-venereologica. Supplementum·2006
Same journal

Atopic hand eczema and treatment strategies.

Acta dermato-venereologica. Supplementum·2005
Same journal

Epidemiology and job-related problems for the eczema patient.

Acta dermato-venereologica. Supplementum·2005
Same journal

Treatment strategies and compliance for the adult patient with atopic eczema.

Acta dermato-venereologica. Supplementum·2005
Same journal

Compliance among patients with atopic eczema.

Acta dermato-venereologica. Supplementum·2005
Same journal

Contact allergic reactions in patients with atopic eczema.

Acta dermato-venereologica. Supplementum·2005
See all related articles

Cellular oncogenes like p53, H-ras, and c-myc show significant activity in psoriasis lesions. However, c-fos expression remains unchanged, suggesting oncogene involvement in psoriasis development.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Oncology

Background:

  • Psoriasis is a chronic inflammatory skin condition with complex pathogenesis.
  • Cellular oncogenes play critical roles in cell growth, proliferation, and differentiation.
  • Understanding oncogene activity in psoriatic lesions may reveal disease mechanisms.

Purpose of the Study:

  • To investigate the expression of specific cellular oncogenes (p53, H-ras, c-myc, c-fos) in psoriatic lesions.
  • To compare oncogene activity in psoriatic skin with normal skin controls.
  • To explore the potential role of these oncogenes in the pathogenesis of psoriasis.

Main Methods:

  • Utilized monoclonal antibodies (MoAbs) for immunohistochemical analysis.
  • Examined frozen sections of psoriatic lesions and normal skin.

Related Experiment Videos

  • Employed a sensitive immunohistochemical method to detect protein expression.

    • Main Results:

    • Remarkable reactivity observed for p53, H-ras, and c-myc in psoriatic plaques.
    • No significant difference in c-fos expression between psoriatic lesions and normal skin.
    • Demonstrated differential expression patterns of key cellular oncogenes in psoriasis.

    Conclusions:

    • The findings suggest a significant involvement of p53, H-ras, and c-myc in the pathogenesis of psoriasis.
    • The lack of altered c-fos expression indicates a specific role for other oncogenes.
    • Highlights the importance of cellular oncogenes in the molecular mechanisms underlying psoriasis.