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Related Experiment Video

Updated: Apr 21, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
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Temporal and spatial expression patterns of bone morphogenetic protein 3 in developing zebrafish.

Midori Ito-Amano1, Yukio Nakamura1, Mika Morisaki1

  • 1Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto 390-8621, Japan.

The Open Rheumatology Journal
|October 21, 2014
PubMed
Summary

Zebrafish bmp3 (zbmp3) expression was studied during development. This gene is highly expressed in developing skeletal tissues, suggesting a role in bone formation.

Keywords:
Bmp3Expression patternsZebrafish.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Bone morphogenetic proteins (BMPs) are crucial signaling molecules in bone biology.
  • Understanding the specific roles of BMPs in skeletal development is essential.

Purpose of the Study:

  • To investigate the expression patterns of zebrafish bmp3 (zbmp3) during embryonic and larval development.
  • To determine the potential role of zbmp3 in zebrafish skeletal development.

Main Methods:

  • Real-time PCR was used to quantify zbmp3 mRNA levels over time.
  • In situ hybridization was employed to visualize the spatial expression of zbmp3 in developing zebrafish embryos.

Main Results:

  • Zebrafish bmp3 (zbmp3) expression was detected from 1 day post-fertilization (dpf) to 2 weeks post-fertilization (wpf), peaking at 1 week.
  • In situ hybridization revealed zbmp3 expression in the otic vesicle from 1 to 5 dpf.
  • Expression was also observed in pharyngeal arch derivatives, including the opercle, branchiostegal ray, and pectoral fins, at 2 dpf.

Conclusions:

  • Zebrafish bmp3 (zbmp3) exhibits dynamic expression during key stages of skeletal development.
  • These findings suggest that zbmp3 plays a significant role in the skeletal biology of developing zebrafish.