Related Experiment Video

Updated: Feb 15, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

429

COUP-TFII and AKT are cancer targets pursued by SCBA award winners

Jim Hu1, Xiao-Fan Wang2

  • 1Hospital for Sick Children, 686 Bay Street, Room 9.9715, Toronto, ON M5G 0A4 Canada.

Cell & Bioscience
|October 21, 2014
PubMed

Insights

This issue reviews COUP-TFII

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Biochemistry

Background:

  • This thematic issue focuses on critical cancer research topics.
  • It features insights from distinguished award winners of the Society of Chinese Bioscientists in America (SCBA) 2013.
  • Key areas include the role of COUP-TFII in cancer and Akt regulation.

Purpose of the Study:

  • To present comprehensive reviews on the roles of COUP-TFII in tumor progression and metastasis.
  • To explore the posttranslational regulation of Akt in human cancer.
  • To highlight the scientific contributions of award-winning researchers.

Main Methods:

  • The issue comprises review articles synthesizing existing research.
  • It does not present new experimental data but rather consolidates knowledge.
  • Focuses on established findings in cancer biology and molecular mechanisms.

Main Results:

  • Review of COUP-TFII's involvement in promoting tumor growth and spread.
  • Analysis of how posttranslational modifications affect Akt signaling in cancer.
  • Recognition of significant advancements by leading scientists in the field.

Conclusions:

  • COUP-TFII is implicated as a key factor in cancer progression and metastasis.
  • Posttranslational modifications of Akt are crucial regulatory events in human cancers.
  • These reviews offer valuable perspectives for future cancer research and therapeutic strategies.

More Related Videos

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

8.0K
Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

11.9K

Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
5.7K
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.5K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.1K