Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

12.5K
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
12.5K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

7.7K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.7K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

2.1K
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
2.1K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

52.8K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
52.8K
Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

48.4K
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
48.4K
Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

74.1K
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
74.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time-dependent changes in monocyte subsets and gene expression patterns are associated with long-term recovery in patients with ischemic stroke.

Research square·2026
Same author

Neuropsychiatric complications 3-4 years after stroke: a population-based study of fatigue, depression and cognition.

BMJ open·2025
Same author

Stroke survivors' preferences regarding study participation in rehabilitation research.

BMC medical research methodology·2022
Same author

Fetal posterior cerebral artery configurations in an ischemic stroke versus an unselected hospital population.

Acta neurologica Scandinavica·2021
Same author

Accurate Prediction of Persistent Upper Extremity Impairment in Patients With Ischemic Stroke.

Archives of physical medicine and rehabilitation·2021
Same author

Genetic Predisposition to Mosaic Chromosomal Loss Is Associated With Functional Outcome After Ischemic Stroke.

Neurology. Genetics·2021

Related Experiment Video

Updated: Apr 21, 2026

Development of Knock-Out Muscle Cell Lines using Lentivirus-Mediated CRISPR/Cas9 Gene Editing
10:12

Development of Knock-Out Muscle Cell Lines using Lentivirus-Mediated CRISPR/Cas9 Gene Editing

Published on: June 16, 2022

3.7K

Stroke genetics: a review and update.

Arne Lindgren1

  • 1Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden. ; Department of Neurology and Rehabilitation Medicine, Skane University Hospital, Lund, Sweden.

Journal of Stroke
|October 21, 2014
PubMed
Summary
This summary is machine-generated.

Understanding stroke genetics is crucial for identifying risks and improving patient outcomes. Research explores genetic variations, familial aggregation, and epigenetic factors influencing stroke susceptibility and recovery.

Keywords:
Genetic Association StudiesGeneticsHumansPharmacogeneticsStroke

More Related Videos

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling
16:43

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling

Published on: March 3, 2013

12.1K
Dissection of Drosophila melanogaster Flight Muscles for Omics Approaches
08:33

Dissection of Drosophila melanogaster Flight Muscles for Omics Approaches

Published on: October 17, 2019

12.7K

Related Experiment Videos

Last Updated: Apr 21, 2026

Development of Knock-Out Muscle Cell Lines using Lentivirus-Mediated CRISPR/Cas9 Gene Editing
10:12

Development of Knock-Out Muscle Cell Lines using Lentivirus-Mediated CRISPR/Cas9 Gene Editing

Published on: June 16, 2022

3.7K
Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling
16:43

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling

Published on: March 3, 2013

12.1K
Dissection of Drosophila melanogaster Flight Muscles for Omics Approaches
08:33

Dissection of Drosophila melanogaster Flight Muscles for Omics Approaches

Published on: October 17, 2019

12.7K

Area of Science:

  • Neurogenetics
  • Molecular Genetics
  • Genomics

Background:

  • Stroke genetics encompasses monogenic and common stroke syndromes, associated conditions (hypertension, atrial fibrillation), familial aggregation, and epigenetic influences.
  • Genetic factors impact stroke risk, specific stroke subtypes (ischemic, hemorrhagic), and recovery.
  • Emerging technologies like next-generation sequencing and epigenetics are advancing stroke genetics research.

Purpose of the Study:

  • To provide an overview of stroke genetics, including various genetic variations influencing stroke risk.
  • To discuss current research methods and emerging technologies in stroke genetics.
  • To highlight recent findings and future prospects in the field of stroke genetics.

Main Methods:

  • Candidate gene studies
  • Genome-Wide Association Studies (GWAS)
  • Family studies
  • RNA and protein analyses
  • Next-generation sequencing
  • Whole genome sequencing
  • Epigenetic analyses
  • Advanced computational methods

Main Results:

  • Single Nucleotide Polymorphisms (SNPs) identified in 2012-2014 are linked to common ischemic stroke risk.
  • Specific SNPs are associated with subtypes like large vessel disease, cardiac embolism, and intracerebral hemorrhage (ICH), including prognosis after ICH.
  • International consortia facilitate large-scale studies, utilizing advanced models to analyze combined SNP effects on stroke risk.

Conclusions:

  • Stroke genetics research is rapidly evolving, with significant progress in identifying genetic risk factors for various stroke types.
  • International collaboration and advanced sequencing technologies are key to unraveling the complex genetic architecture of stroke.
  • Pharmacogenetics and a deeper understanding of genetic influences hold promise for personalized stroke prevention and treatment strategies.