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Arterial stiffness in patients with deep and lobar intracerebral hemorrhage

Maurizio Acampa1, Francesca Guideri1, Ilaria Di Donato1

  • 1Stroke Unit, Department of Neurological and Sensorineural Sciences, Azienda Ospedaliera Universitaria Senese, "Santa Maria alle Scotte" General Hospital, Siena, Italy.

Journal of Stroke
|October 21, 2014
PubMed

Insights

Arterial stiffness, measured by the arterial stiffness index (ASI), was significantly higher in patients with deep intracerebral hemorrhage (ICH) compared to lobar ICH. This suggests arterial stiffening may be a key factor in deep ICH development.

Area of Science:

  • Neurology
  • Cardiovascular Research
  • Stroke Medicine

Background:

  • Intracerebral hemorrhage (ICH) constitutes about 10% of all strokes.
  • Hypertension is implicated in deep ICH (basal ganglia, thalamus, pons, cerebellum) but not lobar ICH.
  • Hypertension reduces arterial elasticity, increasing rupture risk from acute pressure spikes.

Purpose of the Study:

  • To compare arterial stiffness, using the arterial stiffness index (ASI), between patients with deep ICH and lobar ICH.
  • To investigate the role of arterial stiffness in the pathogenesis of different ICH subtypes.

Main Methods:

  • Sixty-four patients with intraparenchymal hemorrhage were enrolled.
  • 24-hour blood pressure and heart rate monitoring was performed.
  • Arterial stiffness index (ASI) was calculated as 1 minus the linear regression slope of diastolic on systolic blood pressure.

Main Results:

  • Patients with deep ICH exhibited significantly higher ASI values (0.64±0.19) compared to those with lobar ICH (0.53±0.17).
  • The difference in ASI between the two groups was statistically significant (P=0.04).

Conclusions:

  • Arterial stiffening appears to be a potential pathogenetic factor in deep ICH.
  • It may contribute to vascular rupture due to elevated intravascular pressure.
  • Therapies targeting arterial stiffness reduction could potentially decrease deep hemorrhagic stroke incidence.
Abstract

Keywords:
Arterial hypertensionArterial stiffnessDeep cerebral hemorrhageHemorrhagic strokeIntracerebral hemorrhageLobar cerebral hemorrhage

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