Related Experiment Video
Updated: Apr 21, 2026
In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility
Published on: April 21, 2022
Serial Spectral Domain Ocular Coherence Tomography Measurement of Outer Nuclear Layer Thickness in Rhegmatogenous
Ian Dooley1, Max Treacy1, Micheal O'Rourke1
1a The Royal Victoria Eye and Ear Hospital , Dublin , Ireland.
Introduction:
The outer nuclear layer (ONL) contains mostly photoreceptor bodies and reduced post-operative ONL thickness (ONLT) is associated with poor visual outcome in rhegmatogenous retinal detachment (RRD).
Methods:
Spectral domain ocular coherence tomography was recorded before and 6 weeks following RRD repair in 27 consecutive patients.
Results:
The repair consisted of combined 20-guage pars plana vitrectomy (PPV) and encirclement in 66.7% of cases, 22.2% underwent PPV alone and 11.1% scleral buckle alone. The mean (± standard deviation) ONLT was reduced in detached retinae (94.1 ± 31.1 microns) compared to the unaffected eye (119.5 ± 26.8 microns). Postoperatively the ONLT increased to 103.3 (± 32.8) microns. ONLT at presentation in the affected eye is significantly and positively correlated with the final ONLT in the affected eye (Pearson's correlation: r = 0.80, p = 0.029).
Conclusion:
The finding that ONLT is reduced in detached retinae carries implications for visual prognosis.
