Related Experiment Video
Updated: Apr 21, 2026

03:37
Iatrogenic Injury Recapitulated: Electroexcision Technique for Urethral Stricture Modeling in Rats
Published on: October 11, 2024
901
Editor's note: notice of retraction.
1Editor-in-Chief, Anesthesia & Analgesia.
Anesthesia and Analgesia
|October 21, 2014
Summary
This study on albumin versus hydroxyethyl starch in cardiopulmonary bypass was retracted due to fabricated data and lack of ethical approval. Research misconduct by Dr. Boldt led to multiple retractions.
Area of Science:
- Anesthesiology and Critical Care Medicine
- Fluid Resuscitation
- Research Integrity
Context:
- A 2009 study compared albumin and hydroxyethyl starch (HES) for cardiopulmonary bypass priming.
- Concerns regarding Institutional Review Board (IRB) approval and data integrity were raised.
- Previous retractions and investigations into Dr. Boldt's work preceded this action.
Purpose:
- To address the retraction of a study comparing albumin and hydroxyethyl starch in cardiopulmonary bypass.
- To inform the scientific community about research misconduct and data fabrication.
- To uphold ethical standards in medical research.
Summary:
- The article "The effects of albumin versus hydroxyethyl starch solution on cardiorespiratory and circulatory variables in critically ill patient" by Boldt J, et al. (Anesth Analg 1996;83: 254–61) is retracted.
- The retraction is based on findings of data manipulation and lack of ethical approval, as determined by Justus-Liebig Universität Giessen and other investigative bodies.
- This action is part of a broader pattern of retractions for Dr. Joachim Boldt due to unethical research conduct.
Impact:
- Highlights the critical importance of ethical research conduct and IRB approval in clinical studies.
- Reinforces the need for rigorous scientific integrity and data verification processes.
- Serves as a cautionary example regarding research misconduct in medical publications.
Related Concept Videos
Clot Retraction and Fibrinolysis
5.9K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
5.9K
Detection of Gross Error: The Q Test
6.8K
When one or more data points appear far from the rest of the data, there is a need to determine whether they are outliers and whether they should be eliminated from the data set to ensure an accurate representation of the measured value. In many cases, outliers arise from gross errors (or human errors) and do not accurately reflect the underlying phenomenon. In some cases, however, these apparent outliers reflect true phenomenological differences. In these cases, we can use statistical methods...
6.8K
Systematic Error: Methodological and Sampling Errors
8.6K
In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
8.6K
Accuracy and Errors in Hypothesis Testing
708
Hypothesis testing is a fundamental statistical tool that begins with the assumption that the null hypothesis H0 is true. During this process, two types of errors can occur: Type I and Type II. A Type I error refers to the incorrect rejection of a true null hypothesis, while a Type II error involves the failure to reject a false null hypothesis.
In hypothesis testing, the probability of making a Type I error, denoted as α, is commonly set at 0.05. This significance level indicates a 5%...
In hypothesis testing, the probability of making a Type I error, denoted as α, is commonly set at 0.05. This significance level indicates a 5%...
708
Proofreading
51.7K
Overview
51.7K
Proofreading
7.5K
Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore, it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase...
Errors During Replication are Corrected by the DNA Polymerase...
7.5K

