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Updated: Apr 21, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
Evolving treatments in multiple myeloma patients with renal failure
Alessandro Gozzetti, Giulia Papini, Veronica Candi
1Hematology, Policlinico "Santa Maria alle Scotte", Viale Bracci 16, 53100 Siena, Italy. gozzetti@unisi.it.
Abstract:
The introduction of novel agents in multiple myeloma therapy has dramatically improved survival in latest years. Great progress has also been detected in particular poor clinical situation such as acute renal failure in which survival was dismal in the past. Treatment with bortezomib, thalidomide and dialysis associated with high cut-off (HCO) filters can recover more than two thirds of myeloma patients with an end stage renal failure. Novel proteasome inhibitors and immunomodulating agents (IMID's) are even more promising in this set of patients. Aim of this review is to provide an overview of treatments of multiple myeloma patients with acute renal failure coming from most recent clinical trials.
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