[Studies of parenteral fat emulsion clearance in peri-operative patients]

In a group of 24 peri-operative patients, all received total parenteral nutrition support (artificial gut support) for 11 days using a mixed energy source (50% from glucose and 50% from liposyn-2/intralipid). Intralipid was used in the fat clearance. A test dose of 10% or 20% Intralipid (Kabivitrum) was administered over a 5 hours period at a dosage of 0.17 +/- 0.017g fat/kg/h. The results show that after 11 days of fat infusion, the fat clearance was accelerated (P less than 0.05). One day after operation(POD + 1), the elimination of fat emulsion was also obviously accelerated (P less than 0.01). Blood chemistry values reflecting organ function did not change following fat emulsion infusion. In this prospective study, Chinese patients well tolerated 50% fat calorie TPN support in the peri-operative period. Patients received satisfactory parenteral nutrition support without high blood glucose side effects in the post-operative period.