[Effect of proglumide (PGM) on bile flow and contents in humans and animals]

Proglumide (PGM) is a CCK/gastrin receptor antagonist. The purpose of this study was to observe the effect of PGM on bile flow and the outputs of bile contents in humans and animals.

1) In patients who had undergone cholecystectomy, bile was collected through T tubes during fasting at 15 min intervals before (control) and after PGM 1.2 ingestion. Drinking water test was done under the same conditions. 2) Dogs and rats were fasted overnight, and the common bile duct was cannulated for bile collection. PGM was given intravenously in bolus. Bile flow, electrolytes, cholesterol, bilirubin, total bile acid, protein and lecithin (content) were measured in humans and dogs. The values were expressed as value per 15 min and compared with control using the Student's t-test. The results show: bile flow, outputs of HCO-3, K+, Na+, CI-, Ca++, cholesterol, bilirubin, total bile acid and protein levels all increased remarkably after PGM administration. In rats, the bile flow increased in a dose response manner between PGM dosages of 100, 200, 400 mg/kg (r = 0.795, P less than 0.001 at 15-30 min). We conclude that PGM has a choleretic effect in human as well as in animals of different species.