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Renal effects of atrial natriuretic factor (99-126) in potassium loaded sheep
N A Yates1, J P Coghlan, B A Scoggins
1Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
Clinical and Experimental Pharmacology & Physiology
|October 1, 1989
Abstract:
1. The renal response to renal arterial infusion of synthetic atrial natriuretic factor (ANF 99-126) was examined in conscious sheep following dietary K loading, and compared with the response in normal sheep. 2. Renal arterial infusion of ANF in K loaded sheep increased the excretion of Na and Ca, but did not affect the excretion of K. 3. The natriuretic effect of ANF was attenuated in K loaded animals, possibly as a consequence of the reduction in Na status which is associated with K loading.