Jove
Visualize
Contact Us

Related Concept Videos

General Transcription Factors01:30

General Transcription Factors

5.8K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.8K
Multiple Allele Traits01:49

Multiple Allele Traits

32.3K
The Concept of Multiple Allelism
32.3K
Transcription Factors02:16

Transcription Factors

70.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
70.3K
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

6.8K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
6.8K
Position-effect Variegation02:32

Position-effect Variegation

5.6K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
5.6K
Genetic Lingo01:11

Genetic Lingo

83.8K
Overview
83.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptomic characterisation of acute myeloid leukemia cell lines bearing the same t(9;11) driver mutation reveals different molecular signatures.

BMC genomics·2025
Same author

Identification of the transcription factor MAZ as a regulator of erythropoiesis.

Blood advances·2021
Same author

JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells.

Blood advances·2021
Same author

Alveolar Macrophage Chromatin Is Modified to Orchestrate Host Response to <i>Mycobacterium bovis</i> Infection.

Frontiers in genetics·2020
Same author

Targeting the RNA m<sup>6</sup>A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.

Cell stem cell·2019
Same author

CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands.

Epigenetics & chromatin·2018
Same journal

Genetic survey of biomarkers at early and mid-pregnancy identifies pregnancy-specialized immune regulation.

PLoS genetics·2026
Same journal

Argonaute proteins orchestrate Meiotic Sex Chromosome Inactivation and timing of the spermatogenic transcriptional program.

PLoS genetics·2026
Same journal

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.

PLoS genetics·2026
Same journal

Microtubule stiffening by the doublecortin-domain protein ZYG-8 contributes to mitotic spindle orientation during zygote division in Caenorhabditis elegans.

PLoS genetics·2026
Same journal

Multiple instance fine-mapping: Predicting causal regulatory variants with a deep sequence model.

PLoS genetics·2026
Same journal

Nuclear ubiquitin-conjugating enzyme TrUbc4 and F-box protein TrFwd1-mediated modification of Cre1 in Trichoderma reesei establishes a regulatory mechanism for carbon catabolite repression.

PLoS genetics·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 21, 2026

CRISPR-Mediated Reorganization of Chromatin Loop Structure
09:20

CRISPR-Mediated Reorganization of Chromatin Loop Structure

Published on: September 14, 2018

14.2K

Uncovering enhancer functions using the α-globin locus.

Douglas Vernimmen1

  • 1The Roslin Institute, Developmental Biology Division, University of Edinburgh, Easter Bush, Midlothian, United Kingdom.

Plos Genetics
|October 21, 2014
PubMed
Summary
This summary is machine-generated.

Studies on globin genes reveal key principles of mammalian gene regulation, including the crucial role of remote regulatory elements in controlling gene expression and DNA looping during cell development.

More Related Videos

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.7K
AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain
09:59

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

Published on: March 31, 2022

2.4K

Related Experiment Videos

Last Updated: Apr 21, 2026

CRISPR-Mediated Reorganization of Chromatin Loop Structure
09:20

CRISPR-Mediated Reorganization of Chromatin Loop Structure

Published on: September 14, 2018

14.2K
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.7K
AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain
09:59

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

Published on: March 31, 2022

2.4K

Area of Science:

  • Genetics
  • Molecular Biology
  • Developmental Biology

Background:

  • Mammalian gene regulation involves complex mechanisms.
  • The α- and β-globin gene clusters are model systems for studying gene regulation.
  • Remote regulatory elements play a significant role in controlling gene expression.

Purpose of the Study:

  • To elucidate the general principles of mammalian gene regulation.
  • To identify and understand the function of remote regulatory elements.
  • To dissect the sequential recruitment of transcription factors during lineage specification.

Main Methods:

  • Studies utilizing both mouse and human α-globin loci.
  • Analysis of transcription factor recruitment.
  • Investigation of RNA polymerase II (PolII) recruitment.
  • Examination of intrachromosomal loop formation.
  • Analysis of polycomb complex removal during differentiation.

Main Results:

  • Demonstrated the importance of remote regulatory elements in recruiting PolII.
  • Showcased the role of remote regulatory elements in generating intrachromosomal loops.
  • Highlighted the function of remote regulatory elements in removing polycomb complexes during differentiation.
  • Revealed the sequential order of transcription factor recruitment during lineage specification.

Conclusions:

  • Remote regulatory elements are critical for orchestrating gene expression.
  • These elements are involved in dynamic chromatin structure changes.
  • Understanding these mechanisms provides insights into mammalian gene regulation and development.