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Updated: Apr 21, 2026

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells
Published on: September 28, 2020
Filamin: a structural and functional biomolecule with important roles in cell biology, signaling and mechanics
Abstract:
Focal adhesions are the immediate sites of the cell's adhesive interaction with the extracellular matrix and as such play a key role in mechanosensing and mechanotransduction at the edge of the cell interface with its surrounding microenvironment. A multitude of proteins orchestrate this mechanochemical communication process between the cell and its outside world. Filamin is a member of focal adhesion protein machinery that also plays a key role in regulating and bundling the acting filament network. A brief review is presented here on filamin and its important protein partners with the aim to shed light on the role of filamin's protein-protein interaction network in cell mechanobiology.
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