Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

11.7K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
11.7K
Protein Organization01:24

Protein Organization

7.2K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
7.2K
Protein Organization01:13

Protein Organization

19.3K
19.3K
Protein Organization01:13

Protein Organization

123.0K
Overview
123.0K
Protein Organization01:24

Protein Organization

8.9K
8.9K
Protein and Protein Structure02:15

Protein and Protein Structure

70.9K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
70.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms for Anti-Inflammatory Activity of Gold Nanoparticles.

Combinatorial chemistry & high throughput screening·2026
Same author

Be the Human in the Loop: Guidance for Scientists in the Emerging Age of Co-Intelligence.

Combinatorial chemistry & high throughput screening·2025
Same author

Criteria and Protocol: Assessing Generative AI Efficacy in Perceiving EULAR 2019 Lupus Classification.

Diagnostics (Basel, Switzerland)·2025
Same author

Prediction of Lupus Classification Criteria via Generative AI Medical Record Profiling.

Biotech (Basel (Switzerland))·2025
Same author

Exploring the Blueprint of Life: The Innovation in Antibody and Protein Design.

Combinatorial chemistry & high throughput screening·2025
Same author

Combinatorial Paths to the Future: A Preface.

Combinatorial chemistry & high throughput screening·2025

Related Experiment Video

Updated: Apr 21, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

70.1K

Comparative modeling of proteins.

Gerald H Lushington1

  • 1LiS Consulting, 2933 Lankford Drive, Lawrence, KS, 66046, USA, glushington@yahoo.com.

Methods in Molecular Biology (Clifton, N.J.)
|October 22, 2014
PubMed
Summary

Protein structure prediction using comparative modeling is crucial for understanding biological functions and diseases. This updated guide details methods for accurate in silico protein structure analysis, aiding biological discovery.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Computational Biology

Background:

  • Protein three-dimensional structure dictates biochemical function in health, medicine, and biotechnology.
  • Understanding protein folding is essential for comprehending biological processes and diseases.
  • Experimental characterization of all proteins is infeasible; in silico prediction is vital.

Purpose of the Study:

  • To provide an updated overview of comparative modeling for protein structure prediction.
  • To detail strategies for achieving reliable and accurate protein models.
  • To discuss advancements in automated computational tools for structure prediction.

Main Methods:

  • Comparative modeling for protein structure prediction.
  • Template selection and sequence/spatial alignment.

More Related Videos

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

1.3K
Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

9.6K

Related Experiment Videos

Last Updated: Apr 21, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

70.1K
Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

1.3K
Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

9.6K
  • Loop, gap, side chain modeling, refinement, and validation.

    • Main Results:

    • Comparative modeling offers efficient and accurate protein structure predictions.
    • Updated strategies enhance the reliability of predicted protein models.
    • Automated tools streamline the protein structure prediction process.

    Conclusions:

    • Protein structure prediction is critical for biological and medical discovery.
    • Comparative modeling remains a key technique for in silico structure analysis.
    • Advancements in computational tools improve the efficiency and accuracy of protein modeling.