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Updated: Apr 21, 2026
Author Spotlight: The Box-Cavity Cortical Approach for Enhanced Evaluation of Biomaterials and Bone Regeneration
Published on: November 21, 2023
Induction of fully stabilized cortical bone defects to study intramembranous bone regeneration
Meghan E McGee-Lawrence1, David F Razidlo
1Department of Cellular Biology and Anatomy, Georgia Regents University, Health Sciences Campus, 1120 15th Street, CB1101, Augusta, GA, 30912, USA, mmcgeelawrence@gru.edu.
Abstract:
Bone is a regenerative tissue with an innate ability to self-remodel in response to environmental stimuli and the need to repair damage. Rodent models of fracture healing, and in particular genetic mouse models, can be used to study the contributions of specific molecular switches to skeletal repair, as well as to recreate and exacerbate biological development and repair mechanisms in postnatal skeletons. Here, we describe methodology for producing fully stabilized, single-cortex defects in mouse femurs to study mechanisms of intramembranous bone regeneration.
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