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Nocturnal stem cell mobilization in patients with obstructive sleep apnoea: a pilot study
Kun-Ta Chou1, Chen-Chi Liu, Han-Shui Hsu
1Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
European Journal of Clinical Investigation
|October 22, 2014
Summary
Patients with obstructive sleep apnoea (OSA) show increased stem cell mobilization during sleep, linked to disease severity. Continuous positive airway pressure (CPAP) therapy may reduce this mobilization.
Area of Science:
- Cardiovascular Science
- Sleep Medicine
- Hematology
Background:
- Obstructive sleep apnoea (OSA) causes intermittent hypoxaemia, oxidative stress, and inflammation, potentially damaging vasculature.
- These insults may trigger repair mechanisms, including stem cell mobilization to peripheral blood.
Purpose of the Study:
- To investigate the nocturnal mobilization of CD34+ stem cells in patients with OSA.
Main Methods:
- Polysomnography was used to assess OSA severity (apnoea-hypopnoea index, AHI).
- Peripheral blood CD34+ cell and SDF-1α levels were measured before and after sleep.
- Stem cell mobilization was quantified by comparing morning and nighttime levels.
Main Results:
- Patients with OSA exhibited significantly higher nocturnal stem cell mobilization compared to controls.
- Mobilization correlated with OSA severity (AHI), BMI, and hypoxaemia parameters.
- Stem cell mobilization and SDF-1α levels decreased after 6 months of CPAP therapy.
Conclusions:
- Nocturnal CD34+ stem cell mobilization occurs in patients with OSA.
- This mobilization is associated with OSA severity and hypoxaemia.
- CPAP therapy may attenuate stem cell mobilization in OSA.
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