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10:04
Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation
Published on: January 12, 2016
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HIV-Associated Neurocysticercosis
Kuljeet Singh Anand1, Ankur Wadhwa2, Jyoti Garg1
1Department of Neurology and Microbiology, Dr. R. M. L. Hospital, New Delhi, India.
Journal of the International Association of Providers of AIDS Care
|October 22, 2014
Summary
Diagnosing neurocysticercosis (NCC) in HIV patients is challenging. However, this study shows successful cysticidal treatment in two HIV-positive individuals with NCC, indicating potential for effective management.
Area of Science:
- Neurology
- Infectious Diseases
- Immunology
Background:
- Co-infection with Human Immunodeficiency Virus (HIV) and neurocysticercosis (NCC) is rare.
- HIV can alter the symptomatic presentation and diagnostic challenges of NCC.
- Individualized management is crucial for HIV patients with NCC, considering disease stage and opportunistic infections.
Observation:
- Two cases of HIV-1 and NCC co-infection are presented.
- Patients presented with seizures and multiple parenchymal lesions, including a large cystic lesion.
- Relatively high CD4 counts (530 and 350 cells/mm³) were noted in both patients.
Findings:
- Diagnosis was supported by enzyme-linked immunosorbent assay (ELISA) and clinical presentation.
- Both patients received cysticidal therapy.
- No patient deterioration was observed during or after treatment.
Implications:
- Successful cysticidal therapy is feasible in HIV-NCC co-infection.
- High CD4 counts may facilitate diagnosis and treatment.
- Further research is needed to understand disease interactions and optimize management strategies.
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