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Synthesis of L-Lys-Aminoxy-Goralatide
Zhiliang Li1, Iryna Lebedyeva, Deqian Zhao
1Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, PO Box: 117200, Gainesville, FL, 32611-7200, USA.
Abstract:
Natural tetrapeptide Goralatide inhibits primitive hematopoietic cell proliferation but reported to be rather unstable in solution (half-life 4.5 min). In this work, we report the synthesis of an aminoxy analog of Goralatide. Aminoxy moiety is expected to provide increased stability and bioavailability of the Goralatide analog.