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Updated: Apr 21, 2026
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
[Patterns and risk factors of recurrence in triple-negative breast cancer]
Feng Yu1, Xiaobei Zhang1, Sheng Zhang1
1Third Department of Breast Cancer, China Tianjin Breast Cancer Prevention, Treatment research center, Tianjin Medical University Cancer Institute and Hospital; Key laboratory of Breast Cancer Prevention & therapy under Ministry of Education; Key Laboratory of Cancer Prevention & Therapy, Tianjin 300060, China.
Objective:
To analyze the recurrence characteristics of triple-negative breast cancer (TNBC) and explore their clinicopathological correlations in northern China.
Methods:
Regression analyses were performed for 4 579 breast cancer patients from September 2002 to September 2007. Among them, there were 787 TNBC patients.
Results:
The median follow-up period was 72 (9-116) months. And 187 (23.8%) TNBC patients recurred and it was significantly different from the recurrence rate of non-TNBC group (17.4%, P = 0.024). The median time to recurrence was 30.2 (4-110) months and 36.3% recurred 2 years while 27.8% did within 2-3 years. The rates of lung, liver and brain metastases to other sites were higher in TNBC patients than those in non-TNBC patients. TNBC patients had higher local recurrence rates than non-TNBC counterparts (2.92% vs 1.56%) (P = 0.009). Age, regional lymph node infiltration, tumor size and pathological stage were all independent prognostic factors of TNBC.
Conclusion:
TNBC has unique recurrence characteristics. It is prone to recur shortly with a high local recurrence rate. Metastatic rate is higher in visceral organ than bone.
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