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A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
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Aptamer-mediated 'turn-off/turn-on' nanozyme activity of gold nanoparticles for kanamycin detection
Tarun Kumar Sharma1, Rajesh Ramanathan, Pabudi Weerathunge
1Ian Potter NanoBioSensing Facility, NanoBiotechnology Research Laboratory, School of Applied Science, RMIT University, GPO Box 2476V, Melbourne VIC 3001, Australia. vipul.bansal@rmit.edu.au.
Chemical Communications (Cambridge, England)
|October 22, 2014
Abstract:
A new ultrafast and highly sensitive 'turn-off/turn-on' biosensing approach that combines the intrinsic peroxidase-like activity of gold nanoparticles (GNPs) with the high affinity and specificity of a ssDNA aptamer is presented for the efficient detection of a model small molecule kanamycin.
