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Updated: Apr 21, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Molecular docking study on platelet-activating factor antagonistic activity of bioactive compounds isolated from
Malina Jasamai1, Juriyati Jalil, Ibrahim Jantan
1a Faculty of Pharmacy, Drugs and Herbal Research Centre, Universiti Kebangsaan Malaysia , Jalan Raja Muda Abd. Aziz, 50300 Kuala Lumpur , Malaysia.
Abstract:
A handful of bioactive compounds from plants have been reported to possess platelet-activating factor (PAF) antagonist activity. However, their mode of action is not well understood. Selected bioactive compounds that exhibit PAF antagonist activity and synthetic PAF antagonists were subjected to docking simulations using the MOE 2007.09 software package. The docking study of PAF antagonists was carried out on the PAF receptor (PAFR) protein which involves in various pathological responses mediated by PAF. The docking results revealed that amentoflavone (3) showed good interactions with the PAFR model where the flavone and phenolic moieties were mostly involved in these interactions. Knowledge on PAF antagonists' interactions with the PAFR model is a useful screening tool of potential PAF antagonists prior to performing PAF inhibitory assay.
