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Updated: Apr 21, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Chiral discrimination of secondary alcohols and carboxylic acids by NMR spectroscopy
Indrani Pal1, Sachin R Chaudhari, Nagaraja Rao Suryaprakash
1NMR Research Centre, Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore, 560012, India.
Abstract:
The manuscript reports two novel ternary ion-pair complexes, which serve as chiral solvating agents, for enantiodiscrimination of secondary alcohols and carboxylic acids. The protocol for discrimination of secondary alcohols is designed by using one equivalent mixture each of enantiopure mandelic acid, 4-dimethylaminopyridine (DMAP) and a chiral alcohol. For discrimination of carboxylic acids, the ternary complex is obtained by one equivalent mixture each of enantiopure chiral alcohol, DMAP and a carboxylic acid. The designed protocols also permit accurate measurement of enantiomeric composition.
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