CD4+ CD56+ Hematodermic Neoplasm Without Cutaneous Involvement

CD4+/CD56+ hematodermic neoplasm is a recently recognized highly aggressive tumor presenting in skin, usually with lymph node and bone marrow involvement, often terminating in a leukemic phase. It has a distinct clinical presentation of primary skin lesions in the form of papules, nodules or bruise like areas. Bone marrow and peripheral blood involvement without skin involvement is a very rare phenomenon. We are reporting an interesting case where an elderly male, a known diabetic, when investigated for the cause of generalised weakness was found to have CD4+/CD56+ hematodermic neoplasm, the unusual feature being absence of any associated cutaneous involvement.