Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multiple Ill-Defined Hypopigmented Scaly Plaques on the Leg in an 8-Year-Old Girl.

Indian journal of dermatology·2026

Same author

Syncytial Variant of Nodular Sclerosis Classical Hodgkin's Lymphoma With Hemophagocytic Lymphohistiocytosis: A Rare and Under-Characterized Entity.

Cureus·2026

Same author

Programmed death ligand-1 (PD-L1) expression in serous ovarian carcinoma with clinicopathological associations.

The Indian journal of medical research·2026

Same author

Beyond H5N1: Influenza A virus infection in bovine udder organoids.

Emerging microbes & infections·2026

Same author

Histomorphological spectrum of Adnexal Tumor with rippled pattern an unusual variant: Report of three cases.

Indian journal of pathology & microbiology·2026

Same author

Maxillofacial tubercular osteomyelitis: diagnostic and therapeutic perspectives from a case series.

BMC infectious diseases·2026

Search research articles

Related Experiment Video

Updated: Apr 21, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

Paediatric idiopathic myelofibrosis.

Annapurna Saksena¹, Prerna Arora¹, Nita Khurana¹

¹Department of Pathology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110002 Delhi India.

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion

|October 22, 2014

Summary

Idiopathic pediatric myelofibrosis is a rare condition in children, often presenting with enlarged spleen and liver. Diagnosis requires excluding secondary causes and confirming marrow fibrosis.

Keywords:

Idiopathic Myelofibrosis Pediatric

More Related Videos

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

Related Experiment Videos

Last Updated: Apr 21, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

Area of Science:

Hematology
Pediatric Oncology

Background:

Pediatric myelofibrosis is a rare hematologic disorder.
It is typically secondary to other conditions, but can be idiopathic.
Idiopathic myelofibrosis is exceptionally rare in children.

Observation:

A case of idiopathic myelofibrosis in a 10-year-old male is presented.
Bone marrow aspirate was dilute, and bone biopsy revealed marrow fibrosis (grade 2-3 reticulin fibers).
Iliac lymph node biopsy showed reactive sinus histiocytosis with extramedullary hematopoiesis.

Findings:

The patient was diagnosed with idiopathic pediatric primary myelofibrosis.
Exclusion of granuloma, parasites, and infiltrative disorders was confirmed.
Acid-fast bacillus stain was negative.

Implications:

This case highlights the importance of considering idiopathic pediatric myelofibrosis.
Suspect this diagnosis in children with progressive pallor, hepatosplenomegaly, and a dry bone marrow tap.
Bone marrow biopsy confirming fibrosis is crucial after excluding secondary causes.