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Updated: Apr 21, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Concurrent chronic lymphocytic leukemia and merkel cell carcinoma in primary skin tumor and metastatic lymph node
Lazar Popovic1, Darjana Jovanovic1, Dragana Petrovic2
1Department for Medical Oncology, Oncology Institute of Vojvodina, Put Dr Goldmana 4, Sremska Kamenica, 21204 Novi Sad, Serbia ; Medical Faculty, University of Novi Sad, Novi Sad, Serbia.
Abstract:
Association between chronic lymphocytic leukemia and other malignancies has been known for a long time. This epidemiological phenomenon is explained by immunosuppression caused by disease itself or by the applied therapy. Merkel cell carcinoma is a rare malignant tumor of the skin of neuroendocrine origin diagnosed almost exclusively in immunocompromised host. We presented an unique case of coexisting infiltration of chronic lymphocytic leukemia cells within primary cutaneous Merkel cell carcinoma and metastatic lymph node in young HIV-negative female patient.
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