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Related Experiment Video

Updated: Apr 21, 2026

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A sample-to-result system for blood coagulation tests on a microfluidic disk analyzer.

Chia-Hui Lin1, Cheng-Yuan Liu2, Chih-Hsin Shih2

  • 1Shaoxing Pushkang Biotechnology Co., Ltd. , No. 398, Mahuan Road, Binhai New Area, Shaoxing, Zhejiang Province 312366, People's Republic of China.

Biomicrofluidics
|October 22, 2014
PubMed
Summary

This study introduces a microfluidic disk analyzer for rapid blood coagulation testing. The device accurately performs prothrombin time (PT) and activated partial thromboplastin time (aPTT) tests on whole blood samples within five minutes.

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Area of Science:

  • Biomedical Engineering
  • Clinical Diagnostics
  • Microfluidics

Background:

  • Traditional blood coagulation tests require complex sample preparation and laboratory instruments.
  • There is a need for rapid, integrated, and automated diagnostic platforms for point-of-care testing.
  • Microfluidic technology offers a potential solution for miniaturizing and automating diagnostic assays.

Purpose of the Study:

  • To describe a novel microfluidic analyzer designed for simultaneous blood coagulation testing.
  • To evaluate the performance of the microfluidic disk analyzer for prothrombin time (PT) and activated partial thromboplastin time (aPTT) assays.
  • To assess the correlation and agreement of results obtained from the microfluidic analyzer with standard hospital instrumentation.

Main Methods:

  • Development of a microfluidic disk integrating sample preparation steps: whole blood aliquoting, metering, plasma separation, decanting, and reagent mixing.
  • Simultaneous execution of prothrombin time (PT) and activated partial thromboplastin time (aPTT) assays on the microfluidic platform.
  • Clinical validation using fifty whole blood samples, comparing results with conventional laboratory methods.

Main Results:

  • The microfluidic analyzer successfully automated sample preparation and reagent handling.
  • Both PT and aPTT tests were completed within a 5-minute turnaround time.
  • Excellent correlation and agreement were observed between the microfluidic disk analyzer and hospital-based instruments for both PT and aPTT measurements.

Conclusions:

  • The developed microfluidic disk analyzer provides a rapid and reliable platform for whole blood coagulation testing.
  • This technology demonstrates potential for efficient point-of-care diagnostics, improving turnaround time for critical patient results.
  • The integrated approach minimizes manual steps, enhancing accuracy and consistency in PT and aPTT measurements.