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Vitamin D levels and left ventricular diastolic function

Anil Pandit1, Farouk Mookadam1, Sailaja Boddu1

  • 1Division of Cardiovascular Diseases , Mayo Clinic , Scottsdale, Arizona , USA.

Open Heart
|October 22, 2014
PubMed

Insights

This study found no significant association between low vitamin D levels and left ventricular diastolic dysfunction in 1011 patients. Further research is needed to explore the relationship between vitamin D and heart health.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nutritional Science

Background:

  • Vitamin D deficiency is linked to cardiovascular diseases like coronary artery disease, LV hypertrophy, and systolic heart failure.
  • Diastolic LV dysfunction is an early indicator of cardiac disease.
  • Previous studies have not investigated the association between vitamin D deficiency and LV diastolic dysfunction.

Purpose of the Study:

  • To determine the association between serum vitamin D levels and left ventricular (LV) diastolic dysfunction.

Main Methods:

  • A retrospective observational study reviewed 1011 patients (679 women).
  • The study examined if low 25-OH-vitamin D levels were associated with LV diastolic dysfunction.

Main Results:

  • No significant differences were observed in LV diastolic dysfunction parameters between patients with vitamin D levels ≤20 ng/mL and those with levels >20 ng/mL.
  • Key parameters analyzed included left atrial volume index, E/e', e' velocity, LV mass index, and deceleration time.

Conclusions:

  • This study found no significant association between vitamin D levels and LV diastolic performance.
  • Despite existing literature linking vitamin D deficiency to cardiovascular disease, this research did not find a link with LV diastolic dysfunction or left atrial volume index.
Abstract

Keywords:
Left ventricular diastolic dysfunctionVitamin D deficiencydiastology

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