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Clinical trials of yeast-derived β-(1,3) glucan in children: effects on innate immunity

Josef Richter1, Vladimir Svozil1, Vlastimil Král1

  • 11 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 2 Sanatorium Edel, Zlaté Hory, Czech Republic ; 3 University of Louisville, Department of Pathology, Louisville, KY, USA.

Annals of Translational Medicine
|October 22, 2014
PubMed

Insights

Oral beta-glucan (β-glucan) supplementation significantly boosted salivary lysozyme, C-reactive protein (CRP), and calprotectin levels in children with chronic respiratory issues, enhancing their mucosal immunity.

Area of Science:

  • Immunology
  • Pediatrics
  • Natural Products

Background:

  • Glucan's role in immune stimulation is recognized.
  • Focus on oral glucan's impact on nonspecific immunity in children with chronic respiratory conditions.

Purpose of the Study:

  • To evaluate the effects of oral beta-glucan on the mucosal immunity of children suffering from chronic respiratory problems.

Main Methods:

  • Salivary levels of albumin, lysozyme, C-reactive protein (CRP), and calprotectin were measured.
  • 60 children (ages 8-12) received a 30-day oral treatment of 100 mg/d glucan.

Main Results:

  • Significant increases in salivary lysozyme, CRP, and calprotectin were observed in children who received glucan.
  • These findings suggest enhanced immune response markers.

Conclusions:

  • Short-term oral administration of beta-glucan effectively stimulates mucosal immunity.
  • This natural immunomodulator shows promise for children with chronic respiratory issues.
Abstract

Keywords:
Glucanchildrenlysozymemucosal immunitysaliva

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