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Related Concept Videos

Crossover Experiments01:16

Crossover Experiments

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Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
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Hand hygiene01:23

Hand hygiene

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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
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Randomized Experiments01:13

Randomized Experiments

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The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
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Standard Precaution01:26

Standard Precaution

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Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
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Cleaning, Sterilization, and Disinfection01:30

Cleaning, Sterilization, and Disinfection

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Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
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Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
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Related Experiment Video

Updated: Apr 21, 2026

Determining Viral Disinfection Efficacy of Hot Water Laundering
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Determining Viral Disinfection Efficacy of Hot Water Laundering

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A randomized crossover trial to decrease bacterial contamination on hospital scrubs.

Mallory A Boutin1, Kerri A Thom, Min Zhan

  • 1Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland.

Infection Control and Hospital Epidemiology
|October 22, 2014
PubMed
Summary
This summary is machine-generated.

Antimicrobial coatings did not reduce bacterial contamination on healthcare worker scrubs. A randomized study found 30% of scrubs were contaminated, with no difference between treated and untreated clothing.

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Area of Science:

  • Infection control
  • Microbiology
  • Healthcare epidemiology

Background:

  • Healthcare worker attire, such as scrubs, can become contaminated with pathogenic microorganisms during clinical practice.
  • Preventing the transmission of infections is a critical aspect of patient safety in healthcare settings.

Purpose of the Study:

  • To evaluate the efficacy of an antimicrobial coating in reducing bacterial contamination on healthcare worker scrubs.
  • To determine if antimicrobial treatment of scrubs can decrease the microbial load on these garments.

Main Methods:

  • A randomized crossover study design was employed.
  • Healthcare worker scrubs were treated with an antimicrobial coating (intervention group) or not (control group).
  • Bacterial contamination levels on scrubs were assessed.

Main Results:

  • Overall, 30% of all assessed scrubs exhibited bacterial contamination.
  • There was no statistically significant difference in the rate of bacterial contamination between the scrubs treated with the antimicrobial coating and the control scrubs.
  • The antimicrobial treatment did not demonstrate a reduction in microbial contamination.

Conclusions:

  • Antimicrobial coatings applied to healthcare worker scrubs did not effectively decrease bacterial contamination in this study.
  • Further research may be needed to explore alternative or improved antimicrobial strategies for healthcare textiles.
  • The findings suggest that current antimicrobial coating technology may not be sufficient to prevent scrub contamination in a clinical environment.